Post-modern pathogens: Surprising activities of translocated effectors from E. coli and Legionella

JS Pearson; Y Zhang; HJ Newton; EL Hartland

Journal article

Post-modern pathogens: Surprising activities of translocated effectors from E. coli and Legionella

JS Pearson, Y Zhang, HJ Newton, EL Hartland

Current Opinion in Microbiology | Published : 2015

DOI: 10.1016/j.mib.2014.11.005

Abstract

Many bacterial pathogens have the ability to manipulate cellular processes and interfere with host cell function through the translocation of bacterial 'effector' proteins. Dedicated protein secretion machines from Gram-negative pathogens, including type III, type IV and type VI secretion systems, inject virulence proteins into infected cells, altering normal cell physiology, including cell structure, metabolism, trafficking and signalling. While effectors were once thought to exert an effect simply by their localization and binding to host cell proteins, increasingly effectors are being recognised as enzymes, in some cases mediating highly novel post-translational modifications on host prot..

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University of Melbourne Researchers

Ying Zhang Author

Hayley Newton Author

Elizabeth Hartland Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

We gratefully acknowledge Ralf Schuelein, Catherine Kennedy and Vicki Bennett-Wood (University of Melbourne) for supplying material for the figures in this review. This work was supported by Australian National Health and Medical Research Council funding awarded to ELH (Grant ID 606788 and 1044061) and HJN (Grant ID 1062383) as well as Australian Research Council funding to ELH (Grant DP130102689). YZ is supported by a University of Melbourne International Research Scholarship (MIRS).